Groundbreaking case report explores Transcranial Pulse Stimulation (TPS) as a novel, non-invasive treatment for treatment-resistant Restless Legs Syndrome (RLS)
We are proud to announce that our Research Team has been published in Frontiers in Human Neuroscience, one of the world’s leading peer-reviewed journals in brain science. The case report, authored by Ellie Mitsi, Petros Kattou, and Sergey Kondratev, presents the first documented case of Transcranial Pulse Stimulation (TPS) applied in treatment-resistant Restless Legs Syndrome (RLS), exploring its feasibility, tolerability, and potential clinical effects.
This publication reflects our ongoing commitment to advancing neuroscience research, improving patient outcomes, and pushing the boundaries of non-invasive brain stimulation therapies.
About the Research
Restless Legs Syndrome (RLS) is a neurological disorder affecting millions of people worldwide, characterised by uncomfortable sensations in the legs and an irresistible urge to move them, typically worsening at night and severely disrupting sleep. RLS can be hard to manage when resistant to conventional treatments — such as medications and physiotherapy — leaving patients without adequate relief and significantly impacting quality of life.
Transcranial Pulse Stimulation (TPS) is an innovative, non-invasive neurostimulation technology that delivers targeted ultrasonic pulse waves to specific regions of the brain. TPS has shown promise in a growing body of clinical research for neurological conditions including Alzheimer’s and Parkinson’s Disease, but its potential as a treatment for Restless Legs Syndrome had not previously been explored in published scientific literature.
Our research team’s case report documents the first clinical application of TPS in a patient with treatment-resistant RLS, presenting a detailed account of the treatment protocol, patient response, and therapeutic outcomes. The findings offer encouraging preliminary evidence that TPS may provide a novel, non-invasive neuromodulatory approach for RLS patients who have not found relief through existing treatments.
SOZO Brain Center: Leading the Way in Neuroscience Research
This publication is a testament to the dedication and scientific rigour of our research team, reinforcing the quality and credibility of the work being done at SOZO Brain Center — and placing us firmly on the international map of neuroscience research and non-invasive brain stimulation.
We are particularly proud that this research focuses on patients who have been underserved by existing treatments. Treatment-resistant RLS can be debilitating, robbing patients of sleep and quality of life. If TPS can offer these individuals meaningful relief, the implications extend far beyond a single case, opening the door to a new therapeutic frontier in non-invasive neuromodulation.
We congratulate Ellie, Petros, and Sergey on this outstanding achievement, and we look forward to building on this foundational work with further clinical research into TPS and Restless Legs Syndrome.
About SOZO Brain Center
SOZO Brain Center is an international hub for clinical excellence, research and education in non-invasive neuromodulation techniques. By utilizing clinically validated, non-invasive brain stimulation, SOZO supports patients suffering from a wide range of neurological, chronic and mental health conditions. These evidence-based therapies include tDCS, taVNS, TPS, CES and more, with extensive scientific research substantiating the medical efficacy of these modalities.
For patients, this medical approach demonstrates measurable improvements in outcomes and substantial long-term reductions in treatment costs. For doctors, they are empowered with drug-free, brain stimulation protocols which can be subsequently offered to their patients for treatment. Our brand name, derived from the ancient Greek word “σῴζω,” means “to save” — reflecting our mission to save patients suffering from chronic, neurological, and mental disorders through advanced neuromodulation techniques.
